The Science Behind Setria Glutathione

Free radical damage affects how well we age. As the body's "master antioxidant," glutathione protects cells against free radical damage, thereby supporting the normal functioning of tissues and organs. Glutathione also plays a key role in detoxification and fortifies the immune system. Not surprisingly, over 80,000 published studies have shown that glutathione plays a central role in good health:

  • High glutathione levels appear to be associated with a long lifespan.1,2
  • Higher levels of glutathione and/or higher dietary intake of glutathione is associated with a healthier heart, eyes, colon, and more.3,4,5,6,7,8
  • Among older individuals, higher glutathione status appear to be associated with multiple measures of good health, including cholesterol, body mass index, blood pressure, blood sugar, and self-ratings of overall health.9

"A little over 50 years ago it was recognized that many chemicals we are exposed to are activated in the body to reactive chemicals. The most central way that the body gets rid of these is by reacting them with glutathione."

– Dr. Dean Jones PhD, Professor of biochemistry, Director of Nutritional Health Sciences, Emory University

Glutathione is at its lowest level in the morning and should be replenished daily through a healthy diet or supplementation such as Setria® Glutathione.

Eur J Nutr. 2014 May 5. [Epub ahead of print]

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

Richie JP Jr1, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE.

Author information
1Department of Public Health Sciences, Penn State Cancer Institute, H069, Penn State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.


Glutathione (GSH), the most abundant endogenous antioxidant, is a critical regulator of oxidative stress and immune function. While oralGSH has been shown to be bioavailable in laboratory animal models, its efficacy in humans has not been established. Our objective was to determine the long-term effectiveness of oral GSH supplementation on body stores of GSH in healthy adults.

A 6-month randomized, double-blinded, placebo-controlled trial of oral GSH (250 or 1,000 mg/day) on GSH levels in blood, erythrocytes, plasma, lymphocytes and exfoliated buccal mucosal cells was conducted in 54 non-smoking adults. Secondary outcomes on a subset of subjects included a battery of immune markers.

GSH levels in blood increased after 1, 3 and 6 months versus baseline at both doses. At 6 months, mean GSH levels increased 30-35 % in erythrocytes, plasma and lymphocytes and 260 % in buccal cells in the high-dose group (P < 0.05). GSH levels increased 17 and 29 % in blood and erythrocytes, respectively, in the low-dose group (P < 0.05). In most cases, the increases were dose and time dependent, and levels returned to baseline after a 1-month washout period. A reduction in oxidative stress in both GSH dose groups was indicated by decreases in the oxidized to reduced glutathione ratio in whole blood after 6 months. Natural killer cytotoxicity increased >twofold in the high-dose group versus placebo (P < 0.05) at 3 months.

These findings show, for the first time, that daily consumption of GSH supplements was effective at increasing body compartment stores of GSH.


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5 Flagg EW et al. Am J Epidemiol. 1994;139(5):453-65.

6 Cohen SM et al. Br J Ophthalmol. 1994 Oct;78(10):791-94.

7 Coral K et al. Eye. 2006 Feb;20(2):203-7.

8 Jonas CR et al. Free Radic Biol Med. 2002;33:1499-506.

9 Julius M et al. J Clin Epidemiol. 1994;47(9):1021-26.

10 Blanco RA et al. Diurnal variation in glutathione and cysteine redox states in human plasma. Am J Clin Nutr. 2007 Oct;86(4):1016-23.of chronically enhancing the body's stores."